The effect of gluten-free diet on mean platelet volume levels as a short-term follow up biomarker in biopsy proven celiac disease patients and its comparison with IgA-tissue transglutaminase antibody levels

Background: Celiac disease is an autoimmune for which there a known environmental trigger i.e., gluten. Adherence to gluten-free diet the mainstay of treatment. Methods: This observational prospective study was conducted in Department Paediatrics, SP Medical College, Bikaner between August 2020 2021. Newly diagnosed celiac patients below 14 years age were included excluding with any associated co-morbid conditions like Diabetes, Hypertension and Hypothyroidism. IgA-tTG titre complete blood counts performed at time diagnosis, repeated after 3 months strict diet. The collected data coded, tabulated analysed. P values < 0.05 statistically significant. Results: mean decreased from 116.28 diagnosis 50.98 (p = <0.001). Also, MPV 9.58 9.19 change significant 0.032). When two biomarkers compared as being better diet, weak positive correlation observed but not 0.212). Conclusions: showed that Mean Platelet Volume (MPV) levels can be used short-term biomarker check adherence